Sleep Problems Melatonin by signaling to the brain that it's time to prepare for sleep, regulating the body's natural sleep-wake cycle (circadian rhythm), 5 Products L-Tryptophan by being converted into serotonin and then melatonin in the brain, which are crucial neurotransmitters and hormones that regulate sleep. 5 Products GABA (Gamma-Aminobutyric Acid) by acting as the brain's primary inhibitory neurotransmitter, reducing neural excitability and promoting a calm, relaxed state conducive to falling and staying asleep. 5 Products 5-HTP (5-Hydroxytryptophan) by being a direct precursor to serotonin, which then converts into melatonin, the hormone that regulates the body's sleep-wake cycle. 5 Products L-Theanine by promoting relaxation and reducing anxiety without causing drowsiness, which in turn facilitates falling asleep and improves sleep quality. 3 Products